The Owls are still playing catch-up following a six-point deduction at the start of the season and are six points from safety with a game in hand.
Opponents Preston are in 11th place, meanwhile, and are six points adrift of the top six with a little under half of the season to go.
Wednesday fell to a 2-0 loss away to Coventry City in their last league outing, ending a four-game unbeaten run that had seen them collect 10 points from a possible 12.
If nothing else, the Owls have at least made Hillsborough a fortress once again, winning three games in a row at home. Not since January 2016 have they won four on the spin there.
The Yorkshire side also have a good record against Preston on home soil, winning five of the last six in the league, although that one defeat did come in the most recent encounter.
Indeed, Preston have won three in a row against Wednesday and are seeking a fourth victory on the bounce in this fixture for the first time since between 1981 and 2002.
The Lilywhites will be confident of extending that winning run as they have taken four points from their last two games to remain in the playoff mix.
Alex Neil's men have conceded just three goals in their last seven league games, compared to 16 conceded in the previous seven.
After firing a blank in their stalemate with Reading last time out, though, Neil will be eager to get his strikers back firing.
Lucas Joao missed a late penalty for Reading in that match and Neil admitted afterwards that his side need to improve in the final third.
Against a Wednesday side that have lost their last two games by a combined five goals without scoring in all competitions, this could be a good chance to do exactly that.
Sheffield Wednesday Championship form: LWDWWL
Sheffield Wednesday form (all competitions): DWWWLL
Preston North End Championship form: WWLLWD
Preston North End form (all competitions): WLLLWD
Wednesday are still without Moses Odubajo after the winger sat out the Coventry match with a hamstring issue.
Versatile forward Callum Paterson has scored in each of his last two home league matches - the only Wednesday player to have scored more than once at Hillsborough in the league this season (four goals).
As for Preston, Greg Cunningham returned to the club on loan from Cardiff City on Thursday and may come straight into the side.
Sean Maguire has missed North End's last two games, meanwhile, and is not expected to feature in this one.
Sheffield Wednesday possible starting lineup:
Westwood; Palmer, Lees, Borner, Penney; Pelupessy, Hutchinson; Reach, Bannan, Green; Windass
Preston North End possible starting lineup:
Iversen; Browne, Huntington, Davies, Rafferty; Ledson, Whiteman; Sinclair, Molumby, Potts; Jakobsen
We say: Sheffield Wednesday 1-2 Preston North End
Wednesday appear to have lost their momentum following back-to-back losses in all competitions, whereas Preston can be happy with their recent form.
The Lilywhites have won three in a row against Wednesday in the league and we are backing them to extend that winning run this weekend.