"It gives us an opportunity to get through to the last 16 and you don't get many opportunities to do that," Clough is quoted as saying by Sky Sports News.
"We can have a real go. It's similar to Villa Park, let's go and enjoy it and have a go.
"They are confirmed favourites, they don't play again until Sunday so it will be interesting to see how they line up. I think they will be much-changed from the one at Bramall Lane."
United drew 1-1 with Fulham when the two sides met last month.