The game marks new manager Gordon Starchan's first competitive fixture in charge of the Tartan Army.
The two teams come into the match with their hopes of progressing from Group A all but over, although a win would give either nation a very slim chance of reaching the World Cup finals.
Meanwhile, Gareth Bale has been passed fit and will start for Wales after struggling with a virus this week.
Scotland: McGregor; Hutton, Mulgrew, Hanley, Caldwell; Dorrans, Snodgrass, McArthur, Maloney, Burke; S Fletcher
Subs: Mackay-Steven, Whittaker, Webster, Adam, Naismith, Miller, Commons, Rhodes, Marshall, Bannan, Martin
Wales: Myhill; Gunter, Ricketts, Williams, Davies; Ramsey, Ledley, Collison, Bale; Robson-Kanu, Bellamy