Flamengo vs. Fortaleza (Wednesday, 11.00pm)
The Scarlet-Black have won 14 of their 22 home games across all competitions in 2021, while the visitors are unbeaten in their last 12 matches on the road.
We say: Flamengo 1-1 Fortaleza
Fortaleza are strong defensively, conceding just four goals in their last 11 matches across all competitions, and they are set to make it a difficult afternoon for the hosts.
However, Flamengo will be keen to bounce back from last weekend's defeat and know that they have the quality in the final third to cause problems.
With little to separate the two sides, a closely-fought score draw could be on the cards at the Maracana Stadium.
Sao Paulo vs. Cuiaba (Wednesday, 11.00pm)
The hosts have failed to win in five attempts in the league this season, while their opponents have also failed to get off the mark in their first three games.
We say: Sao Paulo 2-1 Cuiaba
Both teams are in need of a victory to kickstart their campaigns, especially in the case of Sao Paulo as they seek a first league win under Crespo.
Cuiaba have the ability to hold their opponents to a draw, but we can see the hosts finally getting off the mark with their first three-point haul.
Bragantino vs. Palmeiras (Wednesday, 11.00pm)
In-form sides Bragantino and Palmeiras face off at Estadio Nabi Abi Chedid on Wednesday evening.
Both teams have won back-to-back matches and are separated by just a point at the top end of the Brasileiro standings.
We say: Bragantino 2-2 Palmeiras
Both teams are riding high on the back of late comeback victories last time out, which keeps them each in touching distance of the Brasileiro summit.
Bragantino's two draws this season have been high scoring, and we can see another entertaining contest being played out on Wednesday.
Atletico GO vs. Fluminense (Wednesday, 11.00pm)
The hosts have failed to win any of their last three matches, while the visitors have drawn all of their opening three league games on the road.
We say: Atletico Goianiense 1-1 Fluminense
Both Atletico Goianiense and Fluminense failed to win their last league match and will be keen to bounce back with three points on Wednesday.
However, with little to separate the two sides, a score draw could be on the cards at the Estadio Antonio Accioly.