The Millers have spent the last four weeks inside the bottom three, while the Sky Blues sit just one place above them in 21st and remain in the relegation picture.
Rotherham's hopes of survival remain alive after securing a 3-1 victory against Queens Park Rangers on Tuesday night.
After a goalless first half, Lyndon Dykes broke the deadlock in the 52nd minute, but the game was quickly turned on its head when a two-minute brace from Freddie Ladapo put the hosts in front before Michael Smith sealed the crucial victory in the 90th minute.
That result has moved the Millers to within three points of Thursday's opponents Coventry, and they still have two games in hand.
Rotherham's encounter with the Sky Blues will be the second of four consecutive home matches for Paul Warne's side. However, the Millers have won just five of their 19 matches at the New York Stadium so far this season, the joint-fewest in the division along with Wycombe Wanderers and Preston North End.
Form on home soil has been a problem throughout this campaign, but their next two fixtures against Coventry and Birmingham City on Sunday are matches that Warne will have identified as great opportunities to claim all three points, which would pull them much closer to safety.
Rotherham have won only one of their last four meetings with the Sky Blues, which was a 4-0 home victory in October 2019.
Coventry were unable to build on their 3-1 victory against Bristol City as they were beaten 4-1 away at playoff hopefuls Bournemouth last weekend.
Only Sheffield Wednesday have lost more games on the road than Coventry so far this season, leaving them just outside the relegation zone, with only six games left to play.
Mark Robins's side, who are yet to drop into the bottom three this season, beat Rotherham 3-1 at St Andrew's in December, thanks to strikes from Maxime Biamou, Tyler Walker and a Michael Smith own goal.
Another victory against the Millers would be only their third away from home this campaign, slightly easing any relegation fears for now, as they head down the home straight.
Rotherham boss Warne will consider freshening up the pack following Tuesday's victory against QPR.
Centre-back Richard Wood could come into the starting lineup for Ryan Giles, which would see Wes Harding move to left wing-back, while midfielders Lewis Wing and Jamie Lindsay could also return to the first XI at the expense of Shaun MacDonald and Ben Wiles.
Ladapo is a doubt after suffering a groin strain in midweek, so this could see top goalscorer Smith joined up front by Matt Crooks.
Joe Mattock is back in training after months on the sidelines with an ankle injury, but he is unlikely to feature on Thursday.
Coventry defender Josh Pask is set to miss out on Thursday after being stretchered off in the defeat to Bournemouth with a head injury.
Strikers Walker and Matt Godden have started the last two matches up front together and this partnership is set to stay intact for the trip to the New York Stadium.
Rotherham United possible starting lineup:
Johansson; Robertson, Wood, MacDonald; Olosunde, Lindsay, Wing, Barlaser, Harding; Crooks, Smith
Coventry City possible starting lineup:
Marosi; Ostigard, McFadzean, Hyam; Eccles, Kelly, James, McCallum; O'Hare; Walker, Godden
We say: Rotherham United 2-2 Coventry City
Rotherham have failed to score in seven of their last 11 Championship games, but did score three against QPR on Tuesday, while Coventry have conceded eight goals in their last three league matches.
Securing three precious points for either side would provide a massive boost in their quest to avoid dropping into the third tier.
An open game with both teams pushing to score goals is to be expected on Thursday, and with little to separate the two sides, an entertaining score draw could be on the cards at the New York Stadium.