Rentistas vs. Sao Paulo (Wednesday, 11.00pm)
The home side have not registered a victory in the opening three matches of this year's tournament, managing two draws and one loss.
We say: Rentistas 0-2 Sao Paulo
Sao Paulo are currently on a run of three consecutive draws in all competitions but they will take confidence from defeating Rentistas in gameweek two of the Copa Libertadores.
Rentistas are in need of a victory in this competition and so if they attack the game to chase a goal for themselves, they may leave gaps in their defence which their visitors could capitalise on.
Argentinos Jrs vs. Catolica (Wednesday, 11.00pm)
The away side have only managed one win in their first three fixtures in Group F, having lost in the opening two rounds of the competition.
We say: Argentinos Juniors 2-1 Universidad Catolica
Argentinos Juniors have proven in the first half of fixtures in the Copa Libertadores that they are strong favourites to win Group F and they will want to achieve that as soon as possible so that they can also concentrate on the league.
Universidad will take confidence from scoring three against Nacional which may help them find the back of the net on Wednesday but they may not be strong enough defensively to stop the in-form Avalos.
Fluminense vs. Santa Fe (Thursday, 1.00am)
The last game between the two sides in gameweek two ended in a 2-1 win for Fluminense, who have only recorded one victory along with two draws in Group D.
We say: Fluminense 2-0 Santa Fe
Fluminense are on a 10-game unbeaten run and we expect that to continue on Thursday with another victory over Santa Fe, who have struggled in front of goal in the Copa Libertadores this season.
Kayky is in good form for the home side and Machado's side will be wanting to stay at the summit of Group D heading into the final two games of the group stages.
Deportivo vs. Cerro Porteno (Thursday, 1.00am)
There is currently only one point to split the two sides in Group H, with the hosts having drawn all three games and the visitors registering one win, loss and draw in this season's campaign.
We say: Deportivo La Guaira 1-1 Cerro Porteno
La Guaira are yet to score in this season's Copa Libertadores but after Cerro Porteno conceded four in gameweek three, the visitors showed their defensive frailties which could allow their counterparts to get on the scoresheet on Thursday.
Porteno will need to win this game to stay above their hosts however it will take a lot of character from the squad to bounce back from the 4-0 defeat and the last-minute equaliser they conceded against Nacional last time out.
Junior vs. River Plate (Thursday, 1.00am)
The visitors are only behind Group D leaders Fluminense on goals scored, while their hosts have not registered a win in this season's competition so far.
We say: Atletico Junior 1-1 River Plate
Atletico Junior will want to build upon their 1-1 draw with Fluminense last time out but will also be cautious that River Plate got the better of them in gameweek two.
River Plate themselves need a victory to try to leapfrog Fluminense into top spot in Group D, however a defeat for the visitors would allow their counterparts to draw level on points with them so they may adopt a defensive tactic to ensure they do not lose the game.
Universitario vs. Defensa (Thursday, 3.00am)
The Peruvians have conceded at least three goals in each of their opening three Group A matches, while the Argentinian visitors have conceded six goals in their last two games in all competitions.
We say: Universitario 1-2 Defensa y Justicia
Securing all three points for both Universitario and Defensa y Justicia would greatly improve both teams' chances of qualifying for the knockout stages, although a defeat for the hosts would all but eliminate them from the competition.
Even though the visitors will have a depleted squad, the 11 chosen on the night should be strong enough to secure a narrow victory at the Estadio Monumental.
Atletico Nacional vs. Nacional (Thursday, 3.00am)
Atletico Nacional will be looking to get back to winning ways in Group F of the Copa Libertadores when they host Nacional on Wednesday evening.
The two sides, who have conceded a combined 15 goals in the group stages so far, played out a thrilling 4-4 draw in the reverse fixture last month.
We say: Atletico Nacional 2-2 Nacional
Both defences have looked vulnerable throughout the group stages and goals are to be expected once again on Wednesday night.
With little to separate the two teams, another entertaining score draw could be on the cards at the Estadio Hernan Ramirez Villegas.