Manager Zinedine Zidane makes one other change to the side that thumped Sporting Gijon 5-1 last time out, swapping in Danilo for Dani Carvajal at right-back.
Sergio Ramos had expected to feature in the fixture after returning to training from a calf injury this week, but he is not included in the squad making the trip to Seville.
Real Betis: Adan; Molinero, Pezzella, Bruno, Vargas; N'Diaye, Petros, Kadir, Fabian, Cejudo; Rubén Castro
Subs: Gimenez, Varela, Digard, Portillo, Ceballos, Joaquin, Molina
Real Madrid: Navas; Marcelo, Pepe, Varane, Danilo; Modric, Kroos; James Rodriguez, Ronaldo, Isco; Benzema
Subs: Casilla, Nacho, Caemiro, Carvajal, Kovacic, Vazquez, Jese
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