The league champions came from behind to snatch three points from the Premier League winners in a thrilling 3-2 win at the Bernabeu.
Mourinho is likely to keep a similar side that clinched the victory over City. However, Sergio Ramos may return in defence after he was left out of the side on Tuesday following an alleged bust-up with the Portuguese coach.
Real Madrid: LWWLW
Rayo: Dani; Tito, Casado, Amat, Gonzalez; Carlos, Piti, Trashorras, Fuego, Bille; Baptista
Real Madrid: Casillas; Arbeloa, Pepe, Varane, Marcelo; Khedira, Essien, Alonso; Di Maria, Higuain, Ronaldo
Sports Mole says: 1-2