Hosts La Coruna started brightly and defended well against a threatening Madrid attack, but they were finally undone in a short burst as Cristiano Ronaldo bagged goals either side of James Rodriguez to leave the visitors 3-0 up at half time.
Find out how all of the action developed by reading our minute-by-minute commentary below.
"The team played well [on Tuesday], we scored a lot of goals and tried to play as well as we could. The Bernabeu was content after that performance.
"We have to be positive. I don't hear the booing, but when the supporters sing 'How can I not love you' of course I hear that. I want to live positively. Everyone gets nervous, including the players. It's normal. When you lose the derby it is normal to be nervous. I am not used to losing two games on the bounce with Real Madrid. It is good not to get used to that."