Both teams occupy a place in the relegation zone, but a defeat for visiting Wigan would see them slip five points behind their hosts and at least three from the safety line.
For a club in their position, Wigan have a respectable record on the road so far this season. They've managed to pick up 11 points away from the DW Stadium, scoring 13 goals in the process.
Meanwhile, Reading have been in positive form at the Madejski Stadium of late. They've been unbeaten in their last five outings in Berkshire - a run that dates back to the middle of December.
The Royals have a handful of injury problems for the match, with midfielders Jimmy Kebe and Mikele Leigertwood rated as doubtful. Experienced striker Jason Roberts and goalkeeper Alex McCarthy have already been ruled out.
Possible starting lineups
Reading: Federici; Harte, Mariappa, Pearce, Kelly; McAnuff, Leigertwood, Kebe, Akpan; Pogrebnyak, Hunt
Wigan: Al-Habsi; Boyce, Caldwell, Stam; Beausejour, Scharner, McCarthy, McArthur, Maloney; Gomez, Di Santo
Sports Mole says: 2-1