The newly-promoted side currently sit in the playoff positions, while Reading are languishing near the bottom after a slow start to the campaign.
Reading have drawn two and lost one of their three games so far and it looks like it could be another season of struggle for the Royals.
Steve Clarke took charge last season and guided them to Championship safety, but it has been far from plain sailing for the former West Bromwich Albion boss at the Madejski Stadium.
Reading were fairly unimpressive going forward last season and have started this campaign in a similar way. They have scored just two goals so far, although they have been fairly tight at the back.
Their only home game resulted in a drab 0-0 draw against Leeds United, in which they were far from convincing.
Clarke's men put in an improved display at Sheffield Wednesday in midweek. They look the lead in the 49th minute and led until injury time, when the hosts snatched a point thanks to Modou Sougou's late strike.
Recent form: LDD
MK Dons have been one of the surprise packages of the season so far, showing that they have not been daunted by the step up from League One.
After a disappointing 1-0 defeat to Preston North End, who also came up from League One last season, Karl Robinson's Dons responded with a victory over Bolton Wanderers on Tuesday.
Six points from their opening three games leaves Robinson's men fourth in the table, just a point behind early leaders Ipswich Town and Hull City.
Recent form: WLW
Reading have no fresh injury concerns and could go with the same side that drew at Sheffield Wednesday, despite Jonathan Bond's error costing them the win. Clarke has publicly backed his goalkeeper this week and he is likely to remain in the side.
MK Dons winger Rob Hall was ineligible to feature against parent club Bolton, but he could be brought back in for the trip to the Madejski. Poyet could make his debut in midfield following his loan switch.
Mark Randall is expected to miss out also as he continues his recovery from an injury that he suffered in pre-season.
Reading possible starting lineup:
Bond; Gunter, Ferdinand, McShane, Obita; Norwood, Quinn, Williams, Tshibola, Robson-Kanu; Sa
MK Dons possible starting lineup:
Martin; Spence, McFadzean, Kay, Lewington; Potter, Benavente, Baker, Reeves; Bowditch, Gallagher
Head To Head
The Dons are set to take on many sides for the first time this season, and Reading are one of them. The teams have never met previously.
We say: Reading 0-1 MK Dons
Reading have struggled so far this season, and it is a lack of goals that is costing them. They are displaying a lack of cutting edge in the final third which could hurt them throughout the campaign. The Dons, on the other hand, have continued their momentum gained from winning promotion and look a good bet for another three points here.