Thiago Silva could play a part after returning to action following a hamstring injury, while Edinson Cavani will be available, despite his sending off in the league. Yohan Cabaye could be rested after picking up a knock.
Meanwhile, APOEL will be looking to build on the 1-1 draw with Ajax in their last European outing.
Like PSG, the hosts have a number of players nursing injuries heading into this tie, with Nuno Morais seeking specialist treatment in Serbia for ongoing back and hamstring problems.
Winger Stathis Aloneftis has also been sidelined recently, missing league matches as well as Cyprus's Euro qualifiers against Israel and Wales, but he could return this week.
These two sides previously met in the 1993-94 European Cup Winners' Cup, when PSG secured a 3-0 win on aggregate.
Possible starting lineups
APOEL: Pardo, Sergio, Amorim, Da Cruz, Antoniades, Gomes, Riise, Franco, Djebbour, Manduca, Sheridan
PSG: Sirigu, Van der Wiel, Marquinhos, Bahebeck, Maxwell, Verratti, Aurier, Matuidi, Pasote, Ibrahimovic, Cavani
Sports Mole says: 1-3