Genoa are currently 17th and bottom side Palermo could move to within three points of them with a win.
"I want my team to keep their balance, but to play with more courage, especially against a team like Genoa who are difficult to deal with," Gazzetta dello Sport quotes Malesani as saying.
"Andrea Dossena is not 100% for this game I need my top players. To win it will takes tactical flexibility and a lot of intensity. It will not necessarily decide whether we stay up, but it is very important and I am confident."
Palermo are unbeaten in two games but have not won since November.