Championship side Forest, who have won the competition twice, last got past the third round in 2011.
Meanwhile, League One's Oldham have reached the semi-finals three times - the last occasion coming in 1994.
Sam Hutchinson and Marcus Tudgay are both unavailable for the home side, but David McGoldrick and Jonathan Greening could come into the starting lineup having completed loan spells with Coventry City and Barnsley respectively.
However, Matt Derbyshire is cup-tied after turning out for Oldham earlier in the tournament.
Notts Forest: WDLWDL
Notts Forest: Camp; Harding, Collins, Halford, Ayala; Moussi, Guedioura, Reid, Greening; Cox, Sharp
Oldham: Bouzanis; Grounds, Mvoto, Byrne, Wabara; M'Changama, Croft, Furman, Winchester; Smith, Baxter
Sports Mole says: 2-0