Southampton midfielder Sofiane Boufal is a major doubt for Wednesday night's Premier League home game against Norwich.
The Morocco winger was restricted to bench duty in Saturday's win against Watford after injuring his toe when running into his kitchen table at home last week.
Midfielder Alex Tettey is set to return for Norwich after missing Sunday's 2-2 draw against Arsenal due to family reasons, but Grant Hanley is again missing as he continues his recovery from a groin injury.
Drmic has a hamstring injury and is unlikely to feature again until January.
Southampton provisional squad: McCarthy, Soares, Stephens, Bertrand, Bednarek, Ward-Prowse, Djenepo, Hojbjerg, Redmond, Obafemi, Boufal, Long, Ings, Valery, Yoshida, Gunn, Romeu, Adams.
Norwich provisional squad: Krul, Aarons, Zimmermann, Godfrey, Byram, Trybull, Cantwell, Buendia, McLean, Tettey, Amadou, Hernandez, Pukki, Srbeny, Roberts, Vrancic, Stiepermann, Fahrmann, Lewis.