The Magpies ended a run of poor form with a last-gasp victory over Fulham on Sunday afternoon, which will have boosted their confidence ahead of this European clash.
Benfica, who currently top the Portuguese league by four points, have won their last eight consecutive matches in league and Europe.
Jorge Jesus will probably keep faith with a similar lineup that has seen such success in recent weeks.
Possible starting lineups
Newcastle: Krul; Simpson, Yanga-Mbiwa, Taylor, Santon; Marveau, Cabaye, Sissoko, Gutierrez, Gouffran; Cisse
Benfica: Artur; Almeida, Luisao, Garay, Melgarejo; John, Matic, Andre Gomes; Rodrigo, Oscar Cardozo, Gaitan
Sports Mole says: 2-1