After finishing top of a tricky group that contained Germany and world champions France, the Netherlands are now two games away - with Portugal and Switzerland the other semi-finalists - from a first piece of silverware in three decades.
Here, Sports Mole looks at how Koeman could set out his side for Thursday's match against England in Guimaraes.
England had seven players involved in Saturday's Champions League final between Tottenham Hotspur and Liverpool, compared to two players for the Netherlands - Van Dijk and Wijnaldum.
Given Van Dijk's importance to this team, having formed a solid partnership with Matthijs de Ligt at the back, there is a good chance Koeman will start the Liverpool centre-back this week after just a few training sessions.
Ryan Babel has become a regular under Koeman in the forward line, meanwhile, and there is no reason to suggest that he will lose his place for this big match.
Through the middle, Memphis Depay has had a hand in 21 goals in his last 20 games in all competitions for the Dutch national side.