Depending on results elsewhere, a win could send Fulham second, while Millwall can climb as high as eighth.
Millwall have hit a rocky patch in recent weeks and have taken just one point from their last three league matches, but remain within touching distance of the playoffs.
With just three home defeats all season, Millwall have been consistently solid at the back but struggle to find the net regularly enough and fell to a 2-0 defeat in their most recent match against West Bromwich Albion.
With just 38 goals from 31 matches, only one side in the top half of the table have managed fewer goals, while Gary Rowett's side have won just twice in the league since the turn of the year.
Fulham also ran out 4-0 winners in the reverse fixture, which suggests this could be another tough afternoon for the South London outfit.
Meanwhile, Scott Parker's side are one of the Championship's form sides and have kept a clean sheet in five of their last seven Championship games.
Only outside the automatic promotion places on goal difference, Fulham have won six of their last nine matches in the league and are undefeated in five.
They are also unbeaten in their last four away matches, but have taken just six wins from 15 matches on the road so far this season.
While a win could take them second, such is the congested nature of the playoffs that a defeat could see them end up fifth in the table.
Millwall Championship form: WDWLDL
Millwall form (all competitions): DWLLDL
Fulham Championship form: LWWDWW
Fulham form (all competitions): WWDLWW
Ryan Leonard is being assessed ahead of this match with a leg injury and is now a doubt to play from the start.
Fulham could be without Southampton loanee Harrison Reed because of a calf injury, with the midfielder still being assessed.
Meanwhile, Maxime Le Marchand has been ruled out because of a back injury.
Millwall possible starting lineup:
Bialkowski; Romeo, Hutchinson, Cooper, Wallace; Wallace, Woods, Molumby, Mahoney; Smith, Bradshaw
Fulham possible starting lineup:
Rodak; Odoi, Hector, Ream, Bryan; Johansen, Onomah, Cairney; Cavaleiro, Mitrovic, Reid
We say: Millwall 0-2 Fulham
Fulham are one of the form sides in the league and have the opportunity to move into the automatic promotion spots with a win, which should provide plenty of motivation against a solid but limited Millwall side.
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