For hosts Millwall it's one of two games in hand on the majority and a midweek win over Rovers will guarantee safety. The Lions sit five points clear of the drop zone going into the match after Saturday's drubbing> in Huddersfield.
It's far more complicated for Blackburn who are just a couple of points clear of the bottom three.
They were also on the wrong end of a nasty scoreline on Saturday, going down 4-0 at promotion-chasing Watford.
In the reverse fixture it was Millwall who claimed victory at Ewood Park by two goals to nil.
Possible starting lineups
Millwall: Forde, Smith, Shittu, Beevers, Smith, Osborne, Henry, Woolford, Abdou, Easter, Keogh
Blackburn: Sandomierski, Kane, Dann, Givet, Markus Olsson, King, Jones, Williamson, Dunn, Best, Rhodes
Sports Mole says: 1-1