Rotherham make the trip to the Riverside Stadium sitting in the Championship zone, five points adrift of safety with three matches in hand.
Neil Warnock understandably cut a frustrated figure after watching his Middlesbrough side lose 1-0 at home to Blackburn Rovers on Sunday, their second successive defeat on home territory.
While Boro have still only lost three times in 12 matches at the Riverside Stadium this season, the setbacks against Birmingham City and Blackburn have left the club playing catch-up in the race for promotion.
With the top five all claiming at least seven points from their most recent three fixtures, Middlesbrough are effectively left trying to take advantage of Bournemouth's sudden drop in form.
On a positive note, the North-East outfit are still performing consistently in defence, putting the onus on the forward players to start delivering on a regular basis.
Rotherham endured a frustrating Christmas and New Year period as they were limited to just one fixture in three weeks, which saw them lose 2-1 to Yorkshire rivals Barnsley.
Nevertheless, the Millers have looked refreshed since returning to Championship action, claiming four points from meetings with Derby County and Stoke City.
Despite being five points adrift of safety, Rotherham boss Paul Warne will feel that his players are performing well enough to take advantage of their three games in hand.
With 10 matches in total to be played before the end of February, however, Warne is aware that his side can ill-afford to lose the momentum generated from their recent results.
Middlesbrough Championship form: WLWLWL
Middlesbrough form (all competitions): LWLLWL
Rotherham United Championship form: LWLLWD
Rotherham United form (all competitions): WLLLWD
Having had a week to prepare for this game, Rotherham boss Warne may opt to name the same team which started versus Stoke.
Middlesbrough possible starting lineup:
Bettinelli; Spence, Wood, McNair, Bola; Morsy, Howson, Saville; Tavernier, Assombalonga, Johnson
Rotherham United possible starting lineup:
Blackman; Ihiekwe, Wood, MacDonald; Olosunde, Lindsay, Barlaser, Wiles, Harding; Crooks; Smith
We say: Middlesbrough 2-1 Rotherham United
After their disappointing defeat at the weekend, Warnock will do everything in his power to get a reaction on Wednesday. With that in mind, we expect Boro to battle their way to a hard-fought victory over opponents who will be equally motivated to get out of their own predicament.