The German giants, who are currently in second place in Group F, will guarantee their place in the last 16 if they avoid a heavy defeat and Napoli fail to rout leaders Arsenal in the night's other fixture.
Meanwhile, Marseille start life without manager Elie Baup looking to pick up their first points of the competition following five consecutive defeats.
Dortmund earned themselves a comfortable 3-0 victory when the teams met in Germany two months ago.
Sven Bender misses out for the visitors with a twisted ankle, but Nuri Sahin could recover from ligament damage in time for the match. Ilkay Gundogan, Mats Hummels, Neven Subotic and Marcel Schmelzer remain sidelined.
Possible starting lineups
Marseille: Mandanda; Fanni, Mendes, Diawara, Mendy; Thauvin, Lemina, Imbula, Cheyrou, Payet; Gignac
Dortmund: Weidenfeller; Grosskreutz, Friedrich, Kehl, Durm; Aubameyang, Blaszczykowski, Reus, Piszczek, Mkhitaryan; Lewandowski
Sports Mole says: 0-3