Milinkovic-Savic scored 14 times and provided nine assists during an impressive 2017-18 campaign with Lazio, and a number of clubs - including United and Real Madrid - have been linked with his services.
Lotito has said that the Serbia international "is the best young player" in the world at the moment, and has suggested that the midfielder will not be sold for less than £100m.
"Sergej is the best young player on world scene right now, with huge potential," Lotito told Corriere della Sera.
"I have not received any official bids from AC Milan or Juventus, let alone Madrid or United. Of course, I'm not pushing to sell him but if you ask me how much he is worth then I remember last year I turned down a €110m (£99m) offer.
"How much was Pogba sold to Manchester for? €105m? (£94.4m) Milinkovic-Savic is worth more because he is much better and stronger. And to be clear, I'm not really interested in loan-type arrangements either."
Pogba has been strongly linked with a move to Barcelona in recent days, although it is understood that United are not prepared to sell the World Cup winner for any price.