The Portuguese manager shuffled his pack for the midweek victory over Burton Albion in midweek but today reverts to the same starting XI that delivered a 4-0 victory over Everton last weekend.
That sees Marcus Rashford play alongside Juan Mata and Henrikh Mkhitaryan as support for Romelu Lukaku up front, with Anthony Martial again starting the game on the bench despite scoring against both the Toffees and Albion.
Saints boss Mauricio Pellegrino also names an unchanged side following the 1-0 victory at Crystal Palace last weekend, with Virgil van Dijk again starting the match among the substitutes after eight months out with an ankle injury.
Joining Van Dijk on the bench is Pierre-Emile Hojbjerg, who returns after missing the last game due to the birth of his daughter.
Southampton: Forster; Soares, Hoedt, Yoshida, Bertrand; Lemina, Romeu; Tadic, Davis, Redmond; Long
Subs: McCarthy, Van Dijk, Pied, Ward-Prowse, Hojbjerg, Gabbiadini, Austin
Manchester United: De Gea; Valencia, Bailly, Jones, Young; Matic, Fellaini; Mata, Mkhitaryan, Rashford; Lukaku
Subs: Romero, Blind, Smalling, Carrick, Herrera, Lingard, Martial
Keep up with all of the action from the south coast this afternoon with Sports Mole's live text commentary here.