The United skipper missed Thursday's FA Cup win at Derby after rolling his ankle in training on the eve of the game and will be assessed ahead of the match.
Kevin De Bruyne is doubtful for City after falling awkwardly on his shoulder in the latter stages of the Carabao Cup final last weekend and will be assessed.
Winger Leroy Sane continues to make progress in his recovery from the knee injury that has sidelined him since August but the trip to Old Trafford comes too soon for the German.
Defender Aymeric Laporte is still missing with a hamstring problem. Ederson will return in goal after sitting out the past two domestic cup games.
Manchester United provisional squad: De Gea, Romero, Bishop, Wan-Bissaka, Dalot, Tuanzebe, Fosu-Mensah, Jones, Lindelof, Bailly, Maguire, Shaw, Williams, Fred, Fernandes, Garner, Gomes, McTominay, Matic, Pereira, Mata, Lingard, James, Chong, Greenwood, Ighalo, Martial.
Manchester City provisional squad: Ederson, Bravo, Walker, Cancelo, Stones, Otamendi, Fernandinho, Garcia, Mendy, Zinchenko, Gundogan, Rodri, De Bruyne, D Silva, B Silva, Mahrez, Foden, Sterling, Aguero, Jesus.