United come into the match at the Stadium of Light following Wednesday night's draw against Shakhtar Donetsk in the Champions League.
Managerless Sunderland will also be looking for a win to haul themselves off the bottom of the Premier League.
The Black Cats have lost five of their six league games so far this season, including last Sunday's 3-1 defeat to Liverpool.
For United, Rio Ferdinand and Wayne Rooney could return to the side after both missed the midweek match against Shakhtar. Tom Cleverley may retain his place in the starting XI after completing 90 minutes in Ukraine.
Man Utd: WDLWLL
Possible starting lineups
Sunderland: Westwood; Gardner, Colback, O'Shea, Cuellar; Larsson, Ki, Cattermole, Johnson, Giaccherini; Altidore
Man Utd: De Gea; Rafael, Ferdinand, Vidic, Evra; Nani, Carrick, Cleverley, Kagawa; Rooney; Van Persie
Sports Mole says: 0-2