With that being said, deadline-day capture Marouane Fellaini, who joined the Red Devils from Everton for a reported £27m, could make his full debut for the Premier League champions at Old Trafford.
With Wayne Rooney on the sidelines with a head injury, Danny Welbeck is expected to start in attack alongside Robin van Persie, while Chris Smalling could be installed at right-back for the injured Phil Jones.
Before the close of the transfer window, the Eagles were able to bolster their side with the likes of midfielder Barry Bannan and forward Cameron Jerome on loan from Stoke City, both of whom could feature this weekend.
Manchester United: WDL
Crystal Palace: LLW
Possible starting lineups
Manchester United: De Gea; Smalling, Ferdinand, Vidic, Evra; Carrick, Fellaini; Zaha, Young; Welbeck, Van Persie
Crystal Palace: Speroni; Ward, Gabbidon, Delaney, Moxey; Puncheon, Jedinak, Bannan, Campana; Jerome, Chamakh
Sports Mole says: 3-0