Everton vs. Aston Villa (Saturday, 12.30pm)
The Toffees went down 2-1 to Norwich City in an embarrassing defeat last weekend, while Steven Gerrard's side rescued a point in a 2-2 draw versus Manchester United.
We say: Everton 1-2 Aston Villa
The re-introduction of 'Big Dunc' to the Everton dugout will undoubtedly go down better with the home crowd, but a reinvigorated Villa side will give the interim coach a baptism of fire on Saturday.
Results have not always gone Gerrard's way since his return to the Premier League, but we have confidence in the Lions' ability to prolong Everton's misery with another clinical display in front of goal.
Man Utd vs. West Ham (Saturday, 3.00pm)
In a potentially pivotal game for both sides' top-four hopes, Manchester United and West Ham United prepare for battle at Old Trafford in Saturday's Premier League clash.
We say: Manchester United 2-2 West Ham United
West Ham and low-scoring affairs do not go hand-in-hand, with the hosts' lingering defensive deficiencies there to be exposed by Moyes's relentless crop on Saturday.
However, the Red Devils finally appear to be growing in confidence in the final third again, and we expect an entertaining battle to end with the two sides shaking hands on a point apiece.
Leeds vs. Newcastle (Saturday, 3.00pm)
With discontent growing around the club, Newcastle United continue their battle for Premier League safety with Saturday's trip to Leeds United.
Marcelo Bielsa's side edged a thrilling contest with West Ham United 3-2 last time out, while the Magpies were forced to settle for a point against Watford.
We say: Leeds United 2-1 Newcastle United
In spite of their disappointing bottom-half standing, Leeds have been a tough nut to crack at Elland Road in recent weeks and need no second invitation to attack this leaky Magpies defence.
It is just one frustration after another for Newcastle at this point, who will not roll over and accept defeat on Saturday, but a first away win of the season should continue to elude the Magpies.
Brentford vs. Wolves (Saturday, 3.00pm)
Wolverhampton Wanderers will seek to maintain their charge for a coveted top-four place when they travel to Brentford for Saturday afternoon's Premier League contest.
The Bees suffered a 3-1 defeat to Manchester United in midweek, while Bruno Lage's side came up trumps by the same scoreline against Southampton last weekend.
We say: Brentford 0-2 Wolverhampton Wanderers
Very few teams have experienced much joy in front of goal against Wolves in recent weeks, with Brentford surely needing to take a leaf out of Ward-Prowse's book if they are to spring a surprise on home soil.
Lage's side have generally struggled to assert their authority on rival territory with a number of underwhelming attacking displays, but we can only envisage the visitors maintaining their continental charge with another win and clean sheet this weekend.
Southampton vs. Man City (Saturday, 5.30pm)
Premier League leaders Manchester City will be looking to claim their 13th successive league victory when they face Southampton at St Mary's on Saturday evening.
The Saints, meanwhile, who played out a goalless draw at the Etihad Stadium earlier this season, could move into the top 10 if they were to secure all three points on home soil.
We say: Southampton 0-2 Manchester City
Southampton's point secured against Man City earlier this season will certainly give Hasenhuttl's side belief that they can claim another positive result on Saturday.
However, the Citizens have put together a remarkable run of form and it is difficult to predict anything but an away victory for the Premier League leaders.