Raphael Varane has already been ruled out of the contest with a groin problem that he suffered while representing France over the international break, while Harry Maguire is unlikely to play due to a calf injury, despite returning to first-team training on Friday morning.
Fred and Edinson Cavani will also be unavailable due to international commitments, so Paul Pogba could drop back into midfield alongside Scott McTominay, allowing Jadon Sancho to start on the left, while Cristiano Ronaldo will return at the top end of the field.
The Red Devils will also include Marcus Rashford in their squad for the first time this season, as the England international has returned to full training after recovering from a shoulder operation.
Amad Diallo is also back in training after recovering from a thigh problem and could make the bench.
Manchester United possible starting lineup: De Gea; Wan-Bissaka, Bailly, Lindelof, Shaw; McTominay, Pogba; Greenwood, Fernandes, Sancho; Ronaldo