The Gunners fell to their worst ever Premier League defeat when they visited the Red Devils at the beginning of the 2011-2012 season.
However, Wenger has claimed that loss was down to "special circumstances" and does not expect it to have an influence when a much-changed Arsenal return to the scene of the crime on Saturday.
"Do we want revenge? No," he told The Mirror. "I will not mention last season at all. Ninety per cent of the players who will play on Saturday have not played in this game.
"I believe, of course, there is an emotional aspect to a result like that. But on a footballing front, I don't think you give too much importance to a result like that.
"That's why the emotional meaning is big but the footballing meaning is not very big, and we have had that behind us for a long, long time now."
Read Sports Mole's full preview of tomorrow's clash here.