United make the short trip to the John Smith's Stadium having avoided defeat in their first eight games in the top flight this season, while Huddersfield have failed to win in their last half-a-dozen league matches.
However, Mourinho has said that he is anticipating a difficult game when the newly-promoted side host United on Saturday afternoon.
The 54-year-old told reporters: "We are silly if we don't know what is expected for us, unless it's a new player in the Premier League which we have only Victor Lindelof. Apart from that everybody knows the Premier League and knows what it means to play against newly promoted teams.
"Every team is good and thinks well, that they can win every match against every opponent. The players will be buzzing and the supporters will be happy to have a big club playing in their stadium."
The two clubs will be meeting in a competitive fixture for the first time since 1972.