The £89m midfielder has been left out of the starting lineup for each of the Red Devils' last three matches after falling out of favour under Jose Mourinho.
Pogba is a part of France's 25-man squad for the friendlies against Colombia and Russia, though, and Deschamps admits to being concerned about the 25-year-old's current mindset.
"I don't know what [is wrong]. I'm sure I'll hear about it. Of course, it's a situation he won't be enjoying," he told reporters on Monday afternoon. "As to why or how things came to this, there may be many reasons. I have a great deal of talks with players at our training camps, to gauge their feelings. It's not just Paul.
"But that's what I told [the squad] at midday: what happened at the weekend and before is no longer on the agenda. We have to focus on Russia and Colombia. That's part of our job as coaches.
"Obviously, this is a situation he won't appreciate in relation to everything he's done. There can be many, varied reasons. He can't be happy with what he's going through with his club."