The England striker has missed several training sessions this week as he continues to battle an ankle problem and will be assessed late on.
Deadline-day signing Odion Ighalo will be part of Manchester United's squad.
United fan Ighalo joined on loan until the end of the season on January 31 but has not been training at Carrington due to concerns about the coronavirus.
Chelsea provisional squad: Arrizabalaga, Zouma, Christensen, Rudiger, Tomori, Emerson, James, Azpilicueta, Alonso, Kovacic, Jorginho, Willian, Kante, Abraham, Hudson-Odoi, Mount, Batshuayi, Caballero, Barkley, Pedro, Gilmour, Giroud.
Man Utd Provisional squad: De Gea, Romero, Grant, Wan-Bissaka, Dalot, Bailly, Jones, Maguire, Laird, Lindelof, Shaw, Williams, Matic, Fred, Fernandes, Lingard, James, Mata, Pereira, Chong, Greenwood, Martial, Ighalo.