The Citizens lifted the EFL Cup last weekend with victory over Aston Villa, sandwiched between wins over Real Madrid and Sheffield Wednesday in the Champions League and FA Cup respectively.
Here, Sports Mole rounds up City's latest injury and suspension news ahead of the derby clash at Old Trafford.
Status: Major doubt
Type of injury: Back
Possible return date: March 8 (vs. Manchester United)
Kevin De Bruyne sat out the 1-0 win at Sheffield Wednesday with a back injury sustained in the cup final victory against Villa. Guardiola revealed after Wednesday's match that he is unsure if his star playmaker will be fit enough to feature against United.
Type of injury: Thigh
Possible return date: March 21 (vs. Chelsea)
Aymeric Laporte, who has already spent a significant amount of time on the sidelines this season, hobbled off in the first half against Madrid at the Bernabeu last week. Guardiola has since confirmed that the defender will be out for at least another three weeks with a hamstring injury.
Status: Minor doubt
Type of injury: Knee
Possible return date: Unknown
Leroy Sane has not made an appearance for the Citizens since the 2019 Community Shield, but he did recently make a return for the Under-23s against Arsenal. The German international played 57 minutes of that encounter and should make a return to first-team action sooner rather than later, though perhaps not this weekend.
MAN CITY'S SUSPENSION LIST
City have no suspension concerns ahead of this Premier League showdown.