The first match ended in a 2-2 draw at Old Trafford, and with the winner of the clash at Stamford Bridge facing Manchester City in the last four, both teams will be eager to make it through to a semi-final showdown at Wembley.
With the Premier League title race as good as over, Manchester United manager Sir Alex Ferguson could opt to play his senior players against the Blues.
Manchester United: WWWLDW
Possible starting lineups
Chelsea: Cech; Bertrand, Terry, Cahill, Azpilicueta; Ramires, Mikel, Oscar, Moses, Hazard; Ba
Manchester United: De Gea; Ferdinand, Smalling, Vidic, Evra; Carrick, Giggs, Young, Kagawa; Rooney, Van Persie
Sports Mole says: 1-2