Manchester United have been handed handed a testing Champions League last-16 tie against French champions Paris St Germain.
In the first fixture drawn in Nyon on Monday morning, Premier League champions City were paired against Schalke.
— #UCLdraw (@ChampionsLeague) December 17, 2018
Tottenham, who qualified as runners-up in their group behind Barcelona, will take on current Bundesliga leaders Borussia Dortmund, for whom England teenage forward Jadon Sancho continues to impress.
Following a 3-1 Premier League defeat at Liverpool on Sunday, being paired against runaway Ligue 1 leaders PSG was perhaps not the kindest draw which United boss Jose Mourinho would have been hoping for.
It is, though, the first time the Red Devils will have played the French side, who are unbeaten in their own domestic division this season with some 44 points from 16 league games.
PSG have former United midfielder Angel Di Maria in their squad, as well as Neymar, the world's most expensive player, and France World Cup winner Kylian Mbappe.
Thomas Tuchel's side scored 17 goals in their Group C campaign to qualify ahead of Liverpool, but were beaten 3-2 at Anfield during September.
Bayern Munich, meanwhile, have shown form in Europe, winning Group E, despite their lack of consistency in the Bundesliga, where they are third and trail Dortmund by nine points.
Schalke are down in 13th place, and came through Group D as runners-up.
Manchester City director of football Txiki Begiristain said on the club's social media: "This competition is getting hard. There are big draws and big games coming.
"Teams that are struggling in their league have done very well in the Champions League. German clubs are always very dangerous."
United, Liverpool and Tottenham were all pulled out first in their draw, so will open up with a home game, while City will be away.
Elsewhere in Monday's draw, Atletico Madrid will take on Serie A leaders Juventus, Lyon play Barcelona, Roma face Porto while Dutch club Ajax are set to meet holders Real Madrid.
The first leg fixtures will be split over two midweek dates, on February 12/13 and 19/20, with the second legs played over March 5/6 and 12/13.
Bayern sporting director Hasan Salihamidzic believes the Germans face a "tough nut to crack" in tackling Liverpool.
Salihamidzic said, quoted by UEFA.com: "Liverpool are the hottest team right now and top of the Premier League table.
"They play good football, very physical and with a high tempo. We're looking forward to playing there. These are the challenges you have to master in your career."
The Video Assistant Referee system will be in place for the Champions League knockout stages, having been fast-tracked by the European governing body following successful implementation in other competitions.
UEFA later confirmed the dates of the last-16 ties, which will see United host PSG on February 12, with the second leg in France on March 6.
Spurs host Dortmund on February 13, and will play in Germany on March 5.
Liverpool's first leg against Bayern will be at Anfield on February 19, with the return fixture in the final set of games on March 13.
City head to Schalke on February 20 and are at home on March 12.