The champions could begin the game in third place should Tottenham Hotspur beat Manchester United on Sunday, while Liverpool's triumph over Brighton & Hove Albion on Saturday saw then widen their lead to seven points.
However, City are in scintillating form, having scored an incredible 16 goals without reply in their last two games, and they will be favourites to make it five wins on the bounce in this match.
Here, Sports Mole looks at how Pep Guardiola could line his side up for the contest.
Sergio Aguero is a doubt for the match having been struggling with illness since the win over Liverpool, but he is expected to recover in time and should start despite Gabriel Jesus scoring four in midweek.
Benjamin Mendy could make his return before the end of the month, but this game will come too soon for him and Guardiola must decide whether to continue with Oleksandr Zinchenko or move Laporte into a wider role as he did against Liverpool.