Pep Guardiola's men have been in incredible form over the past two months, last losing a game in November and going five matches without conceding.
The Citizens now turn focus to the FA Cup, with Guardiola expected to rotate his side for this clash against League Two side Cheltenham.
Here, Sports Mole looks at how City could line up at Whaddon Road.
Guardiola has plenty of squad depth across the pitch other than up top, where Gabriel Jesus is likely to be his only available option as Sergio Aguero has tested positive for coronavirus.
The French defender has been struggling with a thigh issue but is now back in training and this seems like a good chance to start rebuilding his fitness.
Kyle Walker and Kevin De Bruyne sustained injuries against Aston Villa on Wednesday, though neither player would likely have played any part in this cup tie.