The Brazilian duo did not take part against Burnley due to their late returns from international duty, and Pep Guardiola has refused to confirm both players' availability for midweek.
However, both Ederson and Jesus ought to be fine to feature after a weekend's rest, but Ferran Torres has been ruled out for at least two months with a foot fracture.
Ederson will certainly take the place of Zack Steffen if fit, while Kyle Walker, Ruben Dias and Oleksandr Zinchenko could also be drafted into the backline, with the latter fit enough to make the bench at the weekend.
Joao Cancelo has played a lot of football this term and could therefore drop out for the Ukrainian, and the same can be said for Bernardo Silva as Ilkay Gundogan eyes a return to the first XI following his return to fitness.
Man City possible starting lineup: Ederson; Walker, Dias, Laporte, Zinchenko; Gundogan, Rodri, De Bruyne; Jesus, Foden, Grealish