Manzano takes over just a day after Joaquin Caparros was sacked from the position and is delighted to be rejoining the club that means "everything" to him.
He told AS: "I am returning to a place which, from a professional point of view, has meant everything to me - not just because of the amount of timer I spent here but also for the great affection I received from everyone here, the matches we went through and time we spent together.
"Everybody here knows that I want the best for this club and for the fans. This is my home, where I have experienced so many things; good times and bad."
Manzano joins Mallorca as they sit 19th, four points from safety in La Liga.