Both nations will head into the contest on the back of late defeats, with Luxembourg having succumbed to a 3-2 loss at the hands of Macedonia last night.
Despite Vicente del Bosque's side suffering defeat, they began their qualifying campaign in emphatic fashion with a 5-1 triumph over Macedonia last month, while Luxembourg are yet to win following their opening-round 1-1 draw with Belarus.
Spain failed to continue their winning run, but La Roja played relatively well in Zilina, which means that changes are likely to be minimal for Sunday's encounter.
One question that has arisen concerns goalkeeper Iker Casillas, who currently has David de Gea knocking on the door, and the Manchester United stopper may enter the fold following the Real Madrid stopper's shaky performance against Slovakia.
Possible starting lineups
Luxembourg: Joubert; Jans, Philipps, Chanot, Krogh Gerson, Janisch; C Martins Pereira, Mutsch, D Turpel, Da Mota; Bensi
Spain: De Gea; Juanfran, Pique, Albiol, Alba; Koke, Busquets, Fabregas; Silva, Costa, Iniesta
Sports Mole says: 1-3