The Hatters are currently four points ahead of the Potters in the Championship table, having made an impressive start to the season.
Jones's 10-month tenure at the bet365 Stadium in 2019 was one to forget, as he won only six out of 38 matches and left the club second from bottom in the Championship.
He returned to Luton in May and has since lost just twice in 13 league games, getting fans back on side after he controversially left Kenilworth Road for Stoke when Luton were second in League One.
They have lost just three times at home in 2020, with James Collins scoring a 91st-minute penalty to earn a 1-1 draw when Stoke last visited Bedfordshire in February.
The result continued Luton's run of eight games without a win against the Potters which dates back to December 2000.
Stoke, now under the stewardship of Michael O'Neill, have started the campaign with one win, two draws and a defeat as they look to make it back to the Premier League at the third time of asking.
Nick Powell's scruffy late equaliser rescued a point last time out in a 1-1 draw with Birmingham City – only their second league goal of the season. This is despite having the highest average possession in the Championship at 56.5%.
Their recent away form is good, with just two defeats in their last nine games on the road – although those losses were 5-0 and 3-0 thrashings at the hands of Leeds United and Wigan Athletic respectively.
Luton Town Championship form: WWLW
Luton Town form (all competitions): WWWLLW
Stoke City Championship form: DLWD
Stoke City form (all competitions): WLWWWD
Nathan Jones is unlikely to make too many changes to a winning team, but Elliot Lee could come back in to start after scoring as a substitute against Wycombe.
Tom Lockyer is aiming to be fit for the game after missing out against the Chairboys and sitting out Wales's games in the international break.
Nick Powell is another player who scored as a substitute two weeks ago, so could replace Tashan Oakley-Boothe in Stoke's starting lineup.
Summer signing Steven Fletcher is still yet to score but his performances have warranted a continued place in the side. The debate comes as to who partners him upfront – Lee Gregory or Tyrese Campbell.
Luton Town possible starting lineup:
Sluga; Cranie, Pearson, Bradley, Norrington-Davies; Rea; Cornick, Berry, Mpanzu, LuaLua; Lee
Stoke City possible starting lineup:
Davies; Chester, Souttar, Fox; Smith, Mikel, Clucas, Powell, McClean; Fletcher, Gregory
We say: Luton Town 1-1 Stoke City
On paper, Stoke's team is packed with more quality and experience than Luton's, but Nathan Jones is getting the best out of the Hatters and will feel he has a point to prove against his old side. A tight game lies in store.