Luton have been poor in the Blue Square Premier since that win, picking up just one point from three league matches, but they will be hoping they can rise to the occasion at Kenilworth Road against Millwall.
Millwall did some giant-killing of their own in the fourth round as they recorded a 2-1 success over Aston Villa.
However, since that win, the Lions have lost three matches in a row in a run that has seen them drop to 12th place in the Championship table.
Luton Town: DWLLDL
Possible starting lineups
Luton Town: Tyler; McNulty, Kovacs, Howells, Henry; Mendy, Martin, Neilson, Smith; Shaw, Gray
Millwall: Forde; Shittu, Lowry, Beevers, Smith; Trotter, Henry, Woolford, Abdou; Marquis, Keogh
Sports Mole says: 1-3