Having returned from Africa Cup of Nations duty, Mane joins up with Roberto Firmino and Philippe Coutinho in the frontline as the Reds look to end a woeful run of form that has seen them win just one of their nine games in all competitions this calendar year.
For the hosts, manager Marco Silva makes four changes from the side that claimed a surprise point at Manchester United in midweek.
Omar Elabdellaoui is preferred to David Meyler at right-back, while deadline-day signings Kamil Grosicki and Alfred N'Diaye come straight into the lineup, with Josh Tymon dropping to the bench and Lazar Markovic ineligible to face his parent club.
Hull City: Jakupovic; Elabdellaoui, Dawson, Maguire, Robertson; Huddlestone; Evandro, Clucas, Grosicki, N'Diaye; Hernandez
Subs: Marshall, Meyler, Ranocchia, Maloney, Mbokani, Niasse, Tymon
Liverpool: Mignolet; Clyne, Matip, Leiva, Milner; Henderson, Can, Lallana; Firmino, Mane, Coutinho
Subs: Karius, Gomez, Moreno, Alexander, Wijnaldum, Origi, Sturridge
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