The Reds visit the Etihad Stadium for a crucial top-four battle, knowing that victory will see them leapfrog their opponents and potentially lift them to second in the table.
Estonia centre-back Klavan, who has started Liverpool's last two games against Arsenal and Burnley, insists that he will respect Aguero, but will not fear him.
The 31-year-old defender told Sky Sports News: "You have to play a little bit differently against Aguero, you can't really storm into duels.
"He is a world-class striker, but a lot of teams in the Premier League have world-class strikers and it's nice to play against them.
"There is always a lot of respect for the strikers I play against, but fear is not the word. Aguero is one of the best for sure. He is great."