The Reds' captain will make the milestone appearance on Sunday afternoon against Newcastle United, and the England skipper has said that it is something that fills him with pride.
"When I was a young boy, I never dreamed I was going to make that many," Gerrard told the club's official website.
"It was all about pulling that red shirt on and making one appearance for the club and then the dream was made.
"So to clock up 600 games is a magnificent achievement for me and my family and everyone is really proud."
Gerrard made his Liverpool debut in 1998 and was given the captain's armband in 2003.