Napoli continued strong at the top of Group D with victory over Legia Warsaw while Borussia Dortmund suffered a shock defeat to Greek side PAOK in just two of this evening's early Europa League kickoffs.
Liverpool remain top of Group B despite a 0-0 away draw to Swiss side Sion, who remain three points clear of third-placed Bordeaux after Gaetan Laborde and Diego Rolan had their goals cancelled out by Maxim Kanunnikov and Vitali Ustinov in a 2-2 draw with Rubin Kazan.
Borussia Dortmund were knocked from the top of Group C after a shock 1-0 home defeat to PAOK, who had Robert Mak's first-half goal to thank for on a memorable night.
In Group D, leaders Napoli made it six wins in six games by beating bottom side Legia Warsaw 5-2 through goals from Chelsea loanee Nathaniel Chalobah, Lorenzo Insigne and Jose Callejon as well as a Dries Mertens brace.
Second-placed FC Midtjylland looked to put themselves five points clear of third, but former Middlesbrough and Burnley frontman Jelle Vossen was on hand to level to give Belgian side Club Brugge a 1-1 draw in Denmark.
Rapid Vienna now top Group E following a 2-1 home win over Dinamo Minsk. Steffen Hofmann had missed a penalty for the hosts just after the 20-minute mark, but Maximilian Hofmann and Matej Jelic were on hand to cancel out Mohammed Abdussalam's second-half goal.
The result sees the Austrian side overtake Villarreal, who drew 3-3 away to Viktoria Plzen after Cedric Bakambu, Jonathan dos Santos and Bruno rescued the Yellow Submarine following goals from Daniel Kolar, Jan Kovarik and Tomas Horava.
Marseille secured a 4-2 victory over Liberec to move five points clear of third place in Group F, with reported Crystal Palace target Michy Batshuayi and 20-year-old midfielder Georges N'Koudou scoring in the first half before Abdelaziz Barrada and Lucas Ocampos put the result beyond doubt in the second, despite the threat of a comeback through Marek Bakos and Josef Sural goals.