Southampton should have new signing Kevin Danso available for the visit of Liverpool.
The Austria defender has joined up with the squad this week after his deadline-day switch from German club Augsburg, while captain Pierre-Emile Hojbjerg should also be involved following illness.
Winger Moussa Djenepo could be set for a debut having been an unused substitute in the 3-0 defeat at Burnley after his summer move from Belgian side Standard Liege and international duty with Mali.
Goalkeeper Adrian is a doubt for Liverpool after an accidental collision with a supporter in the immediate aftermath of the Reds' Super Cup final victory over Chelsea on Wednesday left the Spaniard with a swollen ankle.
Liverpool manager Jurgen Klopp is already without first-choice shot-stopper Alisson Becker because of a calf injury so if Adrian is unavailable at St Mary's then Andy Lonergan is likely to be deployed.
Midfielder Naby Keita will miss out because of a muscle strain.
Southampton provisional squad: Gunn, Vestergaard, Stephens, Bertrand, Bednarek, Valery, Romeu, Ward-Prowse, Redmond, Ings, Adams, McCarthy, Soares, Yoshida, Djenepo, Boufal, Hojbjerg, Obafemi, Danso.
Liverpool provisional squad: Adrian, Lonergan, Kelleher, Hoever, Alexander-Arnold, Van Dijk, Gomez, Robertson, Matip, Henderson, Fabinho, Wijnaldum, Milner, Elliott, Oxlade-Chamberlain, Lallana, Shaqiri, Brewster, Firmino, Mane, Salah, Origi.