The Foxes have lost just once in nine league games this season, while Palace have managed two wins from their last five in the top flight.
Claudio Ranieri's side have shocked everyone with their blistering start to the season, and there are no signs of letting up from the boys in blue.
After going against all the odds and managing to secure Premier League survival under former manager Nigel Pearson last season, the Foxes have been a threat in the top flight.
Leicester opened their account with a thrilling 4-2 victory over Sunderland, and from that point onwards they went on a five-game unbeaten run.
There is a never-say-die attitude within the Leicester team and opponents are wary that Ranieri's side can come back into the game at any moment, case in point being last weekend's match against Southampton.
The concern with Leicester though, is that while they have managed to score 19 goals in nine league games, they have also conceded 16 and have failed to keep a clean sheet in any of their top-flight outings.
There are also questions over Riyad Mahrez's place in the team as the technically-gifted player has been left on the bench for Leicester's last two fixtures, despite his impressive start to the season when he scored four goals in the first three league games.
Vardy is the man of the moment at not only Leicester, but in the division overall as he has scored nine goals - three more than any other player in the league.
With games against Palace, West Bromwich Albion, Watford and Newcastle United coming up, it would be fair to predict that Leicester will still be among the top echelons of the table by December.
Recent form: DWDLWD
Recent form (all competitions): WDWLWD
Alan Pardew rejuvenated the Palace side when he was appointed manager in January, and he has continued that spirit in the early stages of this season.
The Eagles find themselves sixth in the league table following five victories and four defeats in the top flight, and their away form is largely to thank for their position in the standings.
Most teams thrive on a home crowd, and Palace have one of the best atmospheres in the division at Selhurst Park, but at the moment Pardew's side are happy on the road having won nine of their last 12 away fixtures.
Before that, Palace had only managed to gain maximum points from nine out of 61 trips, so this weekend's visit to the King Power Stadium will not be daunting for the London club.
Another positive for Palace is the fact that Leicester have been leaking goals in every league game, which even prompted Pardew to tell reporters this afternoon that there is 'no chance' of a goalless draw.
If Palace can gain all three points against Leicester this weekend, they could move into the top four of the table.
Recent form: WLLWWL
Recent form (all competitions): LLWWWL
The big absentee for the visitors this weekend is Gayle as he serves a suspension after getting sent off against West Ham last Saturday.
Patrick Bamford, who is currently on loan for Chelsea, could be given the chance to prove himself as Pardew so far has not appeared too keen since the forward has not featured prominently following his move to Selhurst Park.
For the home side, the only casualty is Leonardo Ulloa, who is nursing a thigh problem, so Vardy is expected to lead the line once again, and could become only the fifth English player to score more than seven successive Premier League goals.
Leicester City possible starting lineup:
Schmeichel; Simpson, Huth, Morgan, Fuchs; Albrighton, Kante, Drinkwater, Schlupp; Vardy, Okazaki
Crystal Palace possible starting lineup:
Hennessey; Kelly, Dann, Hangeland, Souare; Cabaye, McArthur, Zaha, Puncheon, Bolasie; Bamford
Head To Head
It is tight in the Premier League table with just one point separating these two sides, and it is just as close in the head-to-head records with Leicester and Palace winning 23 games each in all competitions.
There have been 17 draws between the two sides, but last season it was Palace who came out on top with a 1-0 win at the King Power thanks to a 55th-minute goal from Joe Ledley.
Prior to the 2014-15 campaign, the last time that these two teams played one another on Leicester's turf was in 2012 when Palace earned a 2-1 triumph with goals from Damien Delaney and Peter Ramage.
Hit play below to see what the Sports Mole Sofa had to say about this encounter:
We say: Leicester City 2-3 Crystal Palace
As Pardew alluded to today, there seem to be high-scoring games when Leicester are involved, and expect no different when they take on Palace at home this weekend. The difference is, the Eagles are more than comfortable on the road and given the Foxes' open style of play, their opponents could exploit that on Saturday. Palace have kept just two clean sheets in the league this season, while Leicester have conceded a goal in every game. It will be a close encounter and most likely an entertaining one, but Palace could snatch their fourth away win of the campaign.