The 34-year-old will be joined by Stefano Mauri, with Brazilian playmaker Hernanes being deployed just behind the duo, as Lazio look to win their second successive Serie A fixture.
Fabrizio Miccoli will once again spearhead Palermo's forward line and will be partnered in attack by Josip Ilicic.
Steven von Bergen will start in defence for the Sicilian visitors alongside Mauro Cetto, Santiago Garcia and Eros Pisano.
Lazio: Marchetti, Dias, Biava, Lulic, Konko, Ledesma, Gonzalez, Candreva, Klose, Mauri, Hernanes
Palermo: Ujkani, Von Bergen, Cetto, Garcia, Pisano, Barreto, Kurtic, Bertolo, Giorgi, Miccoli, Ilicic