The hosts struggled to break down a stubborn Turkish defence early on, with the Olimpico empty following UEFA sanctions imposed on Lazio.
Look back at a historic night for Aykut Kocaman's side with Sports Mole's minute-by-minute commentary below.
"The Turkish side are not Bayern Munich. It’s a shame it has to be played behind closed doors, as the fans would’ve given Vladimir Petkovic’s lads a real boost.
"With the right mentality, Lazio can do it. I know this squad well and they have the character to achieve this comeback."
He said: "The match we played last week has left us in a good position, and we are confident. We scored two goals without conceding and we have the advantage for this last leg.
"We are proud to be here but we don't want to stop now. We’re able to reach the semi-finals and we can make history, but tomorrow we will have many obstacles: Italian teams are very strong and we are away.
"Also Galatasaray showed us yesterday that all is not over after defeat in the first game."
He said: "We will need courage and patience to impose our style of football and seek a goal as soon as possible. We believe that we can do it.
"I’d say our chances of qualification are less than 50 per cent, but many ties have been overturned in Europe this season and 2-0 is a dangerous result for everyone."
Candreva told reporters at his pre-match press conference: “We played very well there, despite certain incidents and the fiery atmosphere. We believe in our chances of qualification and it is up to us to face this match in the best way possible,” said Candreva in his Press conference.
"There is anger and regret over the first leg, because we could’ve been dealing with a much better result right now.
"We are aware of our strength and believe in qualification. I haven’t scored in a long time, so I hope to break that drought tomorrow night."